Knowra Adult-onset Still's disease Adult-onset Still's disease Adult-onset Still's disease is a rare systemic inflammatory disorder marked by recurring high fevers, joint pain, and a transient salmon-colored rash. It can also cause severe inflammation in organs and tissues.
Interleukin 1 : Interleukin 1 is a family of cytokine proteins that promote inflammation and fever. Excess interleukin 1 signaling is implicated in the disease's systemic inflammation.
Yamaguchi criteria : The Yamaguchi criteria are a clinical classification system used to identify adult-onset Still's disease. They combine fever, rash, joint symptoms, laboratory findings, and exclusion of competing diagnoses.
Sepsis : Sepsis is life-threatening organ dysfunction caused by a dysregulated response to infection. Its fever and inflammatory signs can resemble a flare, but infection drives the illness.
Still's disease : Still's disease is a systemic inflammatory disorder that occurs in both children and adults. The adult-onset form belongs to the same disease spectrum as the childhood form.
Interleukin 6 : Interleukin 6 is a cytokine involved in immune responses, inflammation, and the production of acute-phase proteins. Its inflammatory signaling contributes to fever and elevated inflammatory markers.
Fautrel criteria : The Fautrel criteria are a classification system for adult-onset Still's disease that includes clinical and laboratory features. They offer an alternative framework, including glycosylated ferritin as a supporting marker.
Systemic lupus erythematosus : Systemic lupus erythematosus is a chronic autoimmune disease that can affect multiple organs. It can cause fever, rash, and joint pain, but has different clinical and laboratory patterns.
Systemic juvenile idiopathic arthritis : Systemic juvenile idiopathic arthritis is a childhood inflammatory disease marked by fever, rash, and arthritis. It shares characteristic systemic features and is considered the childhood counterpart of adult-onset disease.
Interleukin 18 : Interleukin 18 is a cytokine that stimulates immune cells to produce interferon gamma. High interleukin 18 levels are associated with the disease and its macrophage activation complications.
Glycosylated ferritin : Glycosylated ferritin is a modified form of ferritin measured as a proportion of total circulating ferritin. A low proportion can support diagnosis when the clinical picture suggests this disease.
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