Knowra Atomoxetine Atomoxetine Atomoxetine is a selective norepinephrine reuptake inhibitor used to treat attention-deficit/hyperactivity disorder. It is a nonstimulant medication that increases norepinephrine signaling by blocking its transporter.
Norepinephrine transporter : A membrane protein that recaptures norepinephrine from synapses into presynaptic neurons. Atomoxetine treats ADHD chiefly by inhibiting this transporter.
Attention-deficit/hyperactivity disorder : A neurodevelopmental disorder characterized by persistent inattention and/or hyperactivity-impulsivity that impairs functioning. Atomoxetine is prescribed to reduce ADHD symptoms across daily settings.
Amphetamine : A stimulant drug that increases release of dopamine and norepinephrine and is used medically for ADHD and other conditions. Unlike amphetamine, atomoxetine does not promote monoamine release and is not a controlled stimulant.
Adverse effect : An unwanted or harmful effect caused by a medication or other intervention. Atomoxetine can cause effects such as gastrointestinal symptoms, reduced appetite, and changes in heart rate or blood pressure.
Norepinephrine : A neurotransmitter and hormone involved in arousal, attention, and stress responses. Blocking its reuptake raises extracellular norepinephrine in relevant brain regions.
ADHD treatment : A set of behavioral, educational, and medication approaches for managing ADHD symptoms and impairment. Atomoxetine is one medication option within broader, individualized ADHD care.
Bupropion : An antidepressant that inhibits norepinephrine and dopamine reuptake and is also used for smoking cessation. Both affect catecholamine signaling, but bupropion is not a selective norepinephrine reuptake inhibitor.
Suicidal ideation : Thoughts about suicide, ranging from passive wishes to die to planning self-inflicted death. Atomoxetine carries a warning about increased suicidal thoughts in children and adolescents, especially early in treatment.
Prefrontal cortex : A set of frontal-lobe regions supporting executive functions such as working memory and behavioral control. Norepinephrine signaling there helps explain atomoxetine’s effects on attention and impulse control.
Stimulant medication : Medication that increases central nervous system activity, including commonly prescribed ADHD drugs such as methylphenidate and amphetamines. Atomoxetine is a nonstimulant alternative to stimulant medicines for ADHD.
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