Knowra Atopic dermatitis Atopic dermatitis Atopic dermatitis is a chronic inflammatory skin disease marked by intense itching and recurring eczema. It involves impaired skin-barrier function and immune dysregulation, with symptoms varying over time.
Skin barrier : The outermost skin defenses that limit water loss and block irritants, allergens, and microbes. Barrier weakness lets irritants and allergens enter while worsening dryness.
Emollient : A topical preparation that softens skin and helps reduce water loss. Regular use supports the barrier between inflammatory flares.
Eczema : A group of inflammatory skin conditions that cause itchy, irritated, or scaly skin. Atopic dermatitis is the most common form of eczema.
Seborrheic dermatitis : A chronic inflammatory skin condition affecting oil-rich areas, often producing greasy scale. Its typical distribution and scale differ from the dry, itchy pattern of atopic dermatitis.
Endotype : A disease subtype defined by a distinct underlying biological mechanism. Atopic dermatitis may comprise biological subgroups that respond differently to treatment.
Filaggrin : A structural protein that helps organize the outer skin layer and maintain its hydration. Filaggrin defects can weaken the barrier and increase atopic dermatitis risk.
Topical corticosteroid : A corticosteroid medicine applied to the skin to reduce inflammation. It is a standard treatment for localized flares.
Skin inflammation : An immune response in skin tissue that can produce redness, swelling, heat, or discomfort. Inflammation underlies the visible lesions and symptoms.
Psoriasis : A chronic immune-mediated disease that produces sharply demarcated, thick scaly plaques. Its plaque morphology and immune pathways differ from atopic dermatitis.
Biomarker : A measurable biological feature that indicates a process, condition, or response to treatment. Reliable biomarkers could help match therapies to disease mechanisms.
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