Aubrey de Grey

Aubrey de Grey is a British biomedical gerontologist known for advocating engineered strategies to repair cellular and molecular damage associated with aging, especially through the SENS framework.

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Senescence-Associated Secretory Phenotype: The inflammatory mixture of signaling molecules released by many senescent cells. Its harmful effects help explain why de Grey treats senescent cells as a target for removal.
SENS: A research framework proposing that aging can be slowed or reversed by repairing seven categories of cellular and molecular damage. De Grey developed this framework to organize his proposed anti-aging interventions.
SENS Research Foundation: A nonprofit organization that funds and conducts research aimed at repairing damage associated with aging. De Grey co-founded the organization to advance research based on his framework.
Life Extension: The pursuit of interventions that extend lifespan or preserve health for longer. De Grey’s proposals are a prominent form of radical life-extension advocacy.
Mitochondrial DNA: The genetic material found in mitochondria, separate from the cell nucleus. Mutations in this DNA form one of the damage categories addressed by SENS.
Senolytic: A drug or treatment that selectively eliminates senescent cells. Senolytics exemplify the cell-removal strategy proposed for senescent-cell accumulation.
Strategies for Engineered Negligible Senescence: A proposed approach to combating aging by periodically repairing accumulated cellular and molecular damage. This expanded formulation captures the central proposal associated with de Grey.
Longevity Escape Velocity: A hypothetical point at which medical advances extend life faster than time passes. De Grey popularized this idea as a possible outcome of repeated advances in rejuvenation medicine.
Advanced Glycation End-Products: Compounds formed when sugars react with proteins or lipids, sometimes cross-linking long-lived tissues. Their accumulation is one of the extracellular damages de Grey proposes to reverse.
Mitochondrial DNA Gene Therapy: A proposed strategy for protecting mitochondrial function by expressing mitochondrial genes from the cell nucleus. It addresses mitochondrial mutations by shifting essential gene copies outside mitochondria.