Behçet's disease

Behçet's disease is a chronic inflammatory disorder that can cause recurrent mouth and genital ulcers, eye inflammation, and disease in blood vessels and other organs. Its symptoms vary among individuals and often recur in flares.

Autoinflammation: Inflammation driven largely by innate immune mechanisms rather than antigen-specific adaptive immune responses. Innate immune activation is one proposed contributor to Behçet's inflammatory flares.
Uveitis: Inflammation of the uvea, the middle layer of the eye, which can threaten vision. Behçet's uveitis may recur and cause permanent visual damage without prompt care.
Vasculitis: Inflammation of blood vessels that can narrow, weaken, or obstruct them. Behçet's disease can inflame vessels of different sizes and types.
Hulusi Behçet: A Turkish dermatologist who described the syndrome of recurrent oral ulcers, genital ulcers, and eye inflammation. His clinical description established the disease's defining triad.
Neutrophil: A white blood cell that rapidly responds to infection and tissue injury and can release inflammatory molecules. Activated neutrophils can contribute to tissue inflammation in Behçet's disease.
Retinal vasculitis: Inflammation of retinal blood vessels that can impair vision. This eye complication can accompany Behçet's disease and requires specialist treatment.
Aphthous ulcer: A shallow, usually painful ulcer of the mouth or other mucosal surface. Behçet's oral ulcers often resemble recurrent aphthous ulcers.
Silk Road: A historical network of trade routes connecting East Asia with the Mediterranean and Europe. Behçet's disease is more prevalent in populations along parts of this route, though it occurs worldwide.
Interleukin 17: A family of immune signaling proteins that promotes inflammation and recruits neutrophils. IL-17 signaling has been implicated in inflammatory activity in Behçet's disease.
Oral ulcer: A break in the lining of the mouth that may be painful and recur. Recurrent oral ulcers are among the most common manifestations of Behçet's disease.

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