Knowra Cannabidiol Cannabidiol Cannabidiol (CBD) is a cannabinoid found in cannabis plants that does not produce the characteristic intoxication of THC. It is used in an approved medicine for certain seizure disorders and studied for other medical effects.
Endocannabinoid system : A network of receptors, signaling molecules, and enzymes that helps regulate functions including pain, mood, and appetite. CBD can influence this signaling system, though it does not act like THC at its main receptors.
Epidiolex : A prescription oral cannabidiol solution approved in the United States for certain seizure disorders. It is the standardized CBD medicine used in pivotal trials and clinical treatment.
Tetrahydrocannabinol : The principal intoxicating cannabinoid in cannabis, commonly abbreviated THC. THC produces intoxication through strong cannabinoid-receptor activity; CBD does not produce the same effect.
CBD oil : An oil-based preparation containing cannabidiol, often sold as a supplement or topical product. Commercial CBD oils vary in concentration, ingredients, and regulatory oversight.
Cannabinoid receptor type 1 : A G-protein-coupled receptor abundant in the brain that mediates many effects of THC. CBD has low direct activity at this receptor, helping distinguish its effects from THC’s.
Lennox–Gastaut syndrome : A severe childhood-onset epilepsy syndrome characterized by multiple seizure types and cognitive impairment. Prescription cannabidiol is approved to treat seizures associated with this syndrome.
Cannabis : A genus of flowering plants that includes varieties cultivated for fiber, seed, and psychoactive or medicinal compounds. Cannabidiol is one constituent of cannabis, whose other compounds and plant varieties differ substantially.
Dietary supplement : A product intended to supplement the diet, subject to rules that differ from those for medicines. Many CBD products are marketed as supplements rather than tested, approved medicines.
Cannabinoid receptor type 2 : A G-protein-coupled receptor found mainly in immune and peripheral tissues, also present in the nervous system. CBD’s relationship with this receptor is indirect and differs from THC’s agonist action.
Dravet syndrome : A rare, severe epilepsy syndrome that usually begins during infancy and is often treatment-resistant. Clinical trials found reduced convulsive seizures with prescription cannabidiol.
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