Knowra Captopril Captopril Captopril is an angiotensin-converting enzyme inhibitor that lowers blood pressure and reduces strain on the heart by limiting formation of angiotensin II.
Angiotensin-converting enzyme : An enzyme that converts angiotensin I into angiotensin II and breaks down bradykinin. Captopril binds this enzyme and inhibits both of its activities.
Hypertension : Persistently elevated arterial blood pressure that increases the risk of cardiovascular and kidney disease. Captopril lowers vascular resistance and is prescribed to treat high blood pressure.
Enalapril : An orally administered ACE inhibitor converted in the body to the active drug enalaprilat. Unlike captopril, it is a prodrug with a longer duration of action.
ACE inhibitor cough : A persistent dry cough that can occur during treatment with ACE-inhibiting drugs. Captopril can cause it because ACE inhibition slows the breakdown of bradykinin.
Renin–angiotensin system : A hormone system that regulates blood pressure, fluid balance, and sodium levels. Captopril acts within this system by preventing angiotensin II formation.
Heart failure : A clinical syndrome in which the heart cannot pump enough blood to meet the body's needs. By reducing afterload and hormonal strain, captopril can improve outcomes in selected patients.
Lisinopril : A long-acting ACE inhibitor used for hypertension, heart failure, and related conditions. It shares captopril's target but generally requires less frequent dosing.
Angioedema : Rapid swelling beneath the skin or mucous membranes that can threaten the airway. ACE inhibitors, including captopril, can rarely trigger this potentially life-threatening reaction.
Angiotensin II : A peptide hormone that constricts blood vessels and promotes aldosterone release. Captopril lowers its production, reducing vasoconstriction and sodium retention.
Diabetic nephropathy : Kidney damage caused by diabetes, often accompanied by albumin leakage into urine. Captopril can slow kidney disease progression in people with diabetes and proteinuria.
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