Carl Ferdinand Cori

Carl Ferdinand Cori was a Czech-American biochemist who shared the 1947 Nobel Prize in Physiology or Medicine with Gerty Cori and Bernardo Houssay for discoveries about glycogen metabolism.

Gerty Cori: Gerty Cori was a biochemist who shared the 1947 Nobel Prize for discoveries about glycogen metabolism. She was Carl Cori’s research partner and wife; their joint work established the Cori cycle.
Cori cycle: The metabolic cycle in which lactate from muscle is transported to the liver, converted to glucose, and returned to muscle. Carl and Gerty Cori characterized this exchange between muscle and liver.
Prague: Prague is the capital of the Czech Republic and a historic center of Central European scholarship. Carl Cori was born and educated in Prague before building his career in the United States.
Nobel Prize in Physiology or Medicine: The Nobel Prize in Physiology or Medicine is an annual award recognizing discoveries in the life sciences and medicine. Cori shared the 1947 prize for discoveries about glycogen metabolism.
Bernardo Houssay: Bernardo Houssay was an Argentine physiologist who shared the 1947 Nobel Prize for discoveries about the role of pituitary hormones in carbohydrate metabolism. He shared the 1947 prize with the Coris for related discoveries in carbohydrate metabolism.
Glycogen metabolism: The synthesis and breakdown of glycogen, the branched glucose-storage polymer found in animals and fungi. His Nobel-recognized discoveries concerned the pathways that build and break down glycogen.
University of Prague: The University of Prague, now Charles University, is a university founded in 1348 in Prague. Cori studied medicine there and earned his medical degree in 1920.
Glycogen storage disease: Glycogen storage diseases are inherited disorders caused by defects in glycogen synthesis or breakdown. The Coris’ enzyme research helped establish the biochemical framework for identifying defects in glycogen metabolism.
Carl and Gerty Cori Laboratory: The laboratory at Washington University where Carl and Gerty Cori conducted influential research in biochemistry. Their laboratory became a center for studying glycogen and carbohydrate metabolism.
Cori ester: Glucose 1-phosphate, an intermediate identified during the enzymatic breakdown of glycogen. The Coris discovered this phosphorylated sugar while investigating glycogen breakdown.

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