Knowra Duloxetine Duloxetine Duloxetine is a serotonin–norepinephrine reuptake inhibitor prescribed for depression, anxiety disorders, and several chronic pain conditions. It increases serotonin and norepinephrine signaling by inhibiting their reuptake.
Serotonin–norepinephrine reuptake inhibitor : A class of medicines that inhibit the reuptake of both serotonin and norepinephrine. Duloxetine belongs to this drug class, which explains its paired neurotransmitter effects.
Major depressive disorder : A mood disorder marked by persistent low mood or loss of interest and associated symptoms. Duloxetine is approved to treat major depressive disorder.
Selective serotonin reuptake inhibitor : A class of antidepressants that primarily inhibit serotonin reuptake. SSRIs target serotonin without duloxetine’s direct norepinephrine reuptake inhibition.
Adverse effects of duloxetine : Unwanted effects associated with duloxetine, including nausea, dry mouth, sleep changes, and sweating. These effects influence whether treatment is tolerated and continued.
Serotonin transporter : A membrane protein that transports serotonin from the synaptic space back into presynaptic cells. Duloxetine inhibits this transporter, increasing serotonin availability between neurons.
Generalized anxiety disorder : An anxiety disorder characterized by excessive, persistent worry across multiple areas of life. Duloxetine is an approved medication option for generalized anxiety disorder.
Venlafaxine : A serotonin–norepinephrine reuptake inhibitor used for depression and anxiety disorders. Venlafaxine shares duloxetine’s drug class but differs in indications and clinical profile.
Serotonin syndrome : A potentially life-threatening reaction caused by excessive serotonergic activity, often involving multiple medicines. Combining duloxetine with other serotonergic drugs can raise this risk.
Norepinephrine transporter : A membrane protein that transports norepinephrine from the synaptic space back into presynaptic cells. Blocking this transporter contributes to duloxetine’s effects on mood and pain signaling.
Diabetic neuropathy : Nerve damage caused by diabetes, often producing pain, tingling, or numbness in the extremities. Duloxetine is used for pain from diabetic peripheral neuropathy.
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