Knowra Dysplasia Dysplasia Dysplasia is disordered cell growth and maturation, often involving atypical cells within an epithelium. It can range from mild abnormalities to severe changes and is not itself invasive cancer.
Epithelial atypia : Structural and nuclear abnormalities in epithelial cells, including variation in cell size, shape, and organization. These abnormalities are the microscopic features used to recognize epithelial dysplasia.
Cervical intraepithelial neoplasia : A spectrum of precancerous squamous abnormalities in the uterine cervix, graded by epithelial involvement. It is a common, graded example of epithelial dysplasia detected through screening.
Carcinogenesis : The multistep process by which normal cells acquire changes that enable malignant growth. Dysplasia can be an intermediate stage in some pathways to cancer.
Neoplasia : Abnormal, relatively autonomous tissue growth that forms a neoplasm. Dysplasia describes abnormal maturation and growth, but does not always constitute a neoplasm.
Histopathology : The microscopic study of diseased tissues to diagnose and characterize disease. Dysplasia is identified by examining tissue architecture and cell appearance.
Barrett's esophagus : A condition in which the lower esophageal lining is replaced by intestinal-type epithelium, sometimes with dysplasia. Surveillance focuses on detecting dysplasia in this metaplastic lining.
Invasive carcinoma : A malignant epithelial tumor that has breached its basement membrane and entered surrounding tissue. Invasion, absent in dysplasia, changes both diagnosis and clinical implications.
Cell differentiation : The process by which cells acquire specialized structures and functions. Disordered maturation is central to the meaning of dysplasia.
Carcinoma in situ : A severe epithelial neoplasm confined to its original tissue layer, without invasion through the basement membrane. It marks a boundary dysplasia may approach, but it is a distinct diagnosis.
Colorectal adenoma : A benign gland-forming colorectal neoplasm that can contain dysplasia and develop into colorectal cancer. Its dysplastic epithelium can progress toward invasive cancer over time.
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