Knowra Edward Calvin Kendall Edward Calvin Kendall Edward Calvin Kendall (1886–1972) was an American biochemist who isolated thyroxine and adrenal cortical compounds, including Compound E, later identified as cortisone.
Cortisone : A corticosteroid hormone and anti-inflammatory drug, also called Compound E in Kendall’s research. Kendall isolated Compound E, which was later identified as cortisone.
Adrenal cortex : The outer region of the adrenal gland that produces steroid hormones. Kendall’s hormone investigations focused on substances produced in this tissue.
Mayo Clinic : A nonprofit medical center in Rochester, Minnesota, known for clinical care and biomedical research. Kendall conducted much of his hormone research at its laboratories.
Philip S. Hench : An American physician whose research established cortisone’s effects in rheumatoid arthritis. Hench supplied the clinical evidence that complemented Kendall’s biochemical research.
Rheumatoid arthritis : A chronic autoimmune disease that causes inflammation of joints and other tissues. Early cortisone treatment produced striking improvements in patients with this disease.
Corticosteroid : A class of steroid hormones and medicines that regulate metabolism, immunity, and inflammation. Several adrenal compounds Kendall isolated belong to this broader class.
Thyroxine : The principal hormone produced by the thyroid gland, also called T4. Before his adrenal work, Kendall isolated crystalline thyroxine from thyroid tissue.
Eugene C. Kendall : An American physician and politician, distinct from biochemist Edward Calvin Kendall. The shared name can cause confusion with Edward Calvin Kendall.
Philip Hench : An American physician who demonstrated cortisone’s therapeutic effects in rheumatoid arthritis. Hench’s clinical work showed the medical value of compounds Kendall isolated.
Hydrocortisone : The principal glucocorticoid hormone in humans, also known as cortisol. It is a related adrenal hormone distinguished from Kendall’s cortisone isolate.
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