Erythromycin

Erythromycin is a macrolide antibiotic that binds bacterial ribosomes and inhibits protein synthesis. It is used against susceptible bacterial infections, especially when penicillin cannot be used.

50S ribosomal subunit: The large ribosomal subunit that catalyzes peptide-bond formation and helps translate messenger RNA. Erythromycin binds this subunit and disrupts bacterial translation.
Pertussis: A contagious respiratory infection caused by the bacterium Bordetella pertussis. Erythromycin is one treatment option, particularly for limiting transmission when given early.
Azithromycin: A long-acting azalide antibiotic derived from the macrolide class. It has a longer half-life and fewer drug interactions than erythromycin.
Macrolide: An antibiotic family characterized by a large macrocyclic lactone ring and activity against bacterial ribosomes. Erythromycin is the prototype natural member of this antibiotic family.
Bacterial protein synthesis: The process by which bacterial ribosomes translate messenger RNA into proteins. Erythromycin works by interrupting this process.
Chlamydia infection: A sexually transmitted infection caused by the bacterium Chlamydia trachomatis. Erythromycin has been used as an alternative treatment in selected cases, including pregnancy.
Clarithromycin: A macrolide antibiotic used for respiratory infections and in some Helicobacter pylori regimens. It shares erythromycin’s target but is generally more acid-stable and better tolerated.
Antibiotic: A substance that kills bacteria or inhibits their growth. Erythromycin is an antibiotic whose activity depends on bacterial susceptibility.
23S ribosomal RNA: The catalytic RNA component of the bacterial 50S ribosomal subunit. Erythromycin binds near this RNA in the ribosome’s peptide-exit tunnel.
Community-acquired pneumonia: Pneumonia acquired outside hospitals or long-term care facilities. Erythromycin can treat susceptible atypical respiratory pathogens, though resistance limits its role.

Linked from 10 pages