Knowra Fluconazole Fluconazole Fluconazole is a triazole antifungal medication that inhibits fungal lanosterol 14α-demethylase, disrupting ergosterol production and fungal cell membranes.
Lanosterol 14α-demethylase : A fungal cytochrome P450 enzyme that converts lanosterol toward ergosterol, a major fungal membrane sterol. Fluconazole binds this enzyme and blocks a key step in ergosterol synthesis.
Candidiasis : An infection caused by Candida yeasts, ranging from localized mucosal disease to invasive bloodstream infection. Fluconazole treats several Candida infections, though species and resistance affect its suitability.
Itraconazole : A triazole antifungal used for several yeast and mold infections, with different absorption and interaction profiles from fluconazole. Its broader activity against some fungi contrasts with fluconazole’s generally limited mold coverage.
Drug interaction : A change in a medication’s effects or concentration caused by another drug or substance. Fluconazole inhibits human drug-metabolizing enzymes, raising concentrations of some co-administered medicines.
Ergosterol : A sterol that stabilizes fungal cell membranes and supports membrane-protein function. Fluconazole reduces ergosterol production, weakening normal fungal membrane function.
Cryptococcosis : A potentially severe infection caused by Cryptococcus fungi, often affecting the lungs or central nervous system. Fluconazole is used in selected treatment phases and to prevent relapse after initial therapy.
Voriconazole : A triazole antifungal used for serious mold and yeast infections, including invasive aspergillosis. Voriconazole covers Aspergillus, whereas fluconazole does not provide reliable treatment for it.
QT interval : A measure on an electrocardiogram representing the time for ventricular depolarization and repolarization. Fluconazole can prolong the QT interval, especially alongside other risk factors or interacting drugs.
Azole antifungal : An antifungal drug that disrupts fungal sterol synthesis by inhibiting lanosterol 14α-demethylase. Fluconazole belongs to this drug family and shares its principal target.
Vulvovaginal candidiasis : A Candida infection of the vulva and vagina that commonly causes itching, irritation, and discharge. A single oral fluconazole dose is a common treatment for uncomplicated cases.
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