Knowra Helicobacter pylori eradication Helicobacter pylori eradication Helicobacter pylori eradication is combination treatment intended to eliminate Helicobacter pylori from the stomach, usually using acid suppression and multiple antimicrobial agents.
Proton pump inhibitor : A drug that reduces stomach acid by inhibiting the gastric hydrogen-potassium ATPase. Acid suppression supports antibiotic activity and is a standard part of many eradication regimens.
Peptic ulcer disease : A condition involving an open sore in the lining of the stomach or upper small intestine. Eradicating H. pylori helps heal infection-associated ulcers and reduces their recurrence.
Helicobacter pylori : A spiral-shaped bacterium that colonizes the stomach lining and can cause chronic gastritis and ulcers. Eradication targets this bacterium, whose stomach survival depends partly on urease.
Susceptibility-guided therapy : Antimicrobial treatment selected using laboratory evidence of a pathogen’s drug susceptibility. It can replace empirical regimen selection when H. pylori susceptibility results are available.
Bismuth quadruple therapy : An H. pylori regimen combining a proton pump inhibitor, bismuth, tetracycline, and metronidazole. It is a widely used regimen, especially when clarithromycin resistance is likely or unknown.
Gastric cancer : Cancer that begins in the stomach, most commonly as adenocarcinoma. Treating H. pylori can lower future gastric cancer risk, particularly before precancerous damage advances.
Urease : An enzyme that converts urea into ammonia and carbon dioxide. H. pylori uses urease to buffer acid locally, and diagnostic tests exploit its activity.
Empirical therapy : Treatment chosen before the causative organism’s specific drug susceptibility is known. Many eradication regimens are empirical, so local resistance patterns guide drug choice.
Clarithromycin triple therapy : An H. pylori regimen combining a proton pump inhibitor, clarithromycin, and amoxicillin or metronidazole. This historically common option is now limited by clarithromycin resistance and local susceptibility.
Gastric MALT lymphoma : A lymphoma of mucosa-associated lymphoid tissue that can arise in the stomach. Some early cases regress after H. pylori is eliminated because the infection sustains lymphoma growth.
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