Hodgkin lymphoma

Hodgkin lymphoma is a cancer of the lymphatic system marked by malignant Hodgkin and Reed–Sternberg cells, usually arising in lymph nodes.

Reed–Sternberg cell: A large abnormal cell, typically derived from a B lymphocyte, that defines classical Hodgkin lymphoma. These malignant cells are the defining microscopic feature of the disease.
Germinal center: A temporary structure in lymph nodes where activated B cells mutate antibody genes and undergo selection. The cell of origin for classical disease is usually a B cell altered in this environment.
Lymph-node biopsy: A procedure that removes lymph-node tissue for microscopic and laboratory examination. Tissue examination establishes the diagnosis and reveals the characteristic malignant cells.
Nodular lymphocyte-predominant B-cell lymphoma: An indolent B-cell lymphoma formerly called nodular lymphocyte-predominant Hodgkin lymphoma. It was historically grouped with Hodgkin lymphoma but has distinct tumor cells and biology.
Cancer survivorship: The experience and care of people living with or beyond cancer and its treatment. Long-term follow-up matters because many patients live for decades after treatment.
Lymph node: A small immune organ that filters lymph and provides sites for immune-cell activation. Hodgkin lymphoma most often begins in lymph nodes.
NF-κB: A family of transcription factors that regulate inflammation, immunity, cell survival, and proliferation. Constitutive NF-κB activity helps Hodgkin and Reed–Sternberg cells avoid cell death.
Ann Arbor staging: A system that describes lymphoma extent by involved lymph-node regions and disease beyond them. Stage helps summarize how far Hodgkin lymphoma has spread.
Diffuse large B-cell lymphoma: An aggressive lymphoma in which large abnormal B cells form diffuse sheets in tissue. It can present in lymph nodes but lacks the defining pattern of classical Hodgkin lymphoma.
Secondary cancer: A new, distinct cancer that develops after an earlier cancer or its treatment. Radiation and chemotherapy can raise later risks for additional cancers.

Linked from 7 pages