Knowra Laboratory mouse Laboratory mouse A mouse bred or maintained for scientific research, especially in genetics, medicine, and biology. Its controlled breeding and well-characterized strains make experiments easier to compare.
Inbred strain : A population produced by repeated close-relative mating, yielding animals with highly similar genomes. Genetic uniformity helps isolate experimental effects from inherited variation.
Selective breeding : The practice of choosing animals with desired traits to produce the next generation. It established many research strains with predictable characteristics.
Oncology : The branch of medicine concerned with cancer, its biology, diagnosis, prevention, and treatment. Mouse tumors help investigate cancer development and evaluate candidate therapies.
Rat model : The use of rats in controlled experiments to investigate biology, disease, or treatment. Rats are another mammalian model, often favored for larger body size or distinct behavioral tasks.
Animal welfare : The physical and mental well-being of animals, including their health, comfort, and ability to express behavior. Mouse research raises obligations to reduce suffering and provide appropriate care.
Mouse genome : The complete genetic material of the house mouse, including its genes and noncoding sequences. It provides the reference for mapping mutations and comparing mouse biology with human biology.
Embryonic stem cell : A pluripotent cell from an early embryo that can produce many cell types and contribute to an organism. Embryonic stem cells enabled targeted gene changes in mice.
Immunology : The study of the immune system and its responses to infection, injury, and disease. Mouse strains and mutants allow controlled tests of immune mechanisms.
Zebrafish model : The use of zebrafish to study development, genetics, physiology, or disease experimentally. Zebrafish offer transparent embryos and high-throughput studies, unlike mammalian mice.
Three Rs : The principles of replacement, reduction, and refinement for humane use of animals in research. These principles guide decisions about whether and how mice are used experimentally.
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