Knowra Loratadine Loratadine Loratadine is a second-generation antihistamine that blocks peripheral histamine H1 receptors to relieve allergic symptoms, usually with little sedation at recommended doses.
Histamine H1 receptor : A receptor that mediates many effects of histamine, including itching, sneezing, and increased vascular permeability. Loratadine reduces allergic symptoms by blocking this receptor.
Allergic rhinitis : Inflammation of the nasal lining caused by an allergic response to inhaled substances. Loratadine commonly relieves its sneezing, itching, and runny nose.
Cetirizine : A second-generation antihistamine used to treat allergic rhinitis and hives. It treats similar symptoms but is more likely than loratadine to cause drowsiness.
Sedation : A state of reduced alertness caused by a medicine or other influence. Loratadine is less sedating than many older antihistamines, though drowsiness can still occur.
Histamine : A signaling molecule involved in immune responses, stomach acid secretion, and communication in the nervous system. Histamine release drives many symptoms loratadine is used to relieve.
Urticaria : A skin reaction marked by raised, itchy welts, also known as hives. H1-receptor blockade can reduce the itching and wheals of hives.
Fexofenadine : A second-generation antihistamine used for allergic rhinitis and chronic hives. It is another low-sedation option for many of the same allergic symptoms.
Drug interaction : A change in a drug’s effects caused by another drug, food, or substance. Some medicines that affect loratadine metabolism can change its exposure.
Blood–brain barrier : A selective boundary between blood and brain tissue that limits the passage of many substances. Loratadine enters the brain less readily than older antihistamines, helping limit sedation.
Seasonal allergic rhinitis : Allergic inflammation of the nose triggered by seasonal airborne allergens, such as pollen. Loratadine is commonly taken for pollen-related symptoms.
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