LSD

LSD is a potent synthetic psychedelic lysergamide that alters perception, thought, and mood, often producing vivid changes in sensory experience and a distorted sense of time.

Serotonin 5-HT2A receptor: A serotonin receptor that helps regulate perception, cognition, and mood and is activated by many classic psychedelics. LSD’s psychedelic effects depend substantially on activating this receptor.
Albert Hofmann: A Swiss chemist who synthesized LSD and first documented its psychedelic effects. Hofmann created LSD while researching ergot-derived compounds.
Psychedelic therapy: A therapeutic approach that uses psychedelic substances alongside psychological support. LSD has been investigated as an adjunct to psychotherapy, especially for anxiety and substance use.
Psilocybin: A naturally occurring psychedelic compound found in some mushrooms and converted in the body to psilocin. Both act mainly through serotonin pathways, but psilocybin’s effects usually last less time.
Counterculture of the 1960s: A social movement that challenged prevailing cultural norms in the United States and other countries during the 1960s. LSD became closely associated with the period’s experimentation and political dissent.
Serotonin: A neurotransmitter and signaling molecule involved in mood, sleep, appetite, and sensory processing. LSD resembles serotonin and acts on several of its receptor types.
Ergot alkaloids: A family of compounds produced by ergot fungi, including substances with powerful effects on blood vessels and the nervous system. LSD was developed from structural research on these fungal compounds.
LSD-assisted psychotherapy: A historical and renewed clinical approach pairing LSD administration with structured psychotherapy. It was the main framework for many mid-century therapeutic studies of LSD.
Mescaline: A naturally occurring psychedelic alkaloid found in peyote and some other cacti. Mescaline is another classic psychedelic, with a distinct chemical structure and typically longer onset.
Timothy Leary: An American psychologist and advocate of psychedelic use who became a prominent public figure in the 1960s. Leary’s promotion of LSD helped make it a cultural and political flashpoint.

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