Luis Federico Leloir

Luis Federico Leloir was an Argentine physician and biochemist whose research revealed how sugar nucleotides help organisms synthesize and break down carbohydrates. He received the 1970 Nobel Prize in Chemistry.

Bernardo Houssay: An Argentine physiologist who won the 1947 Nobel Prize in Physiology or Medicine for work on hormones and carbohydrate metabolism. Houssay mentored Leloir and helped establish the institute where Leloir conducted much of his research.
Sugar nucleotide: A molecule in which a sugar is linked to a nucleotide, enabling enzymes to transfer the sugar to another molecule. Leloir’s central discovery showed how these activated sugars participate in carbohydrate synthesis.
University of Buenos Aires: A public university in Argentina, founded in 1821 and based in Buenos Aires. Leloir studied medicine there before turning toward biochemical research.
1970 Nobel Prize in Chemistry: The Nobel Prize in Chemistry awarded to Luis Federico Leloir for discoveries concerning sugar nucleotides and carbohydrate metabolism. The award recognized the findings that established Leloir’s international scientific standing.
Carlos Eugenio Cardini: An Argentine biochemist who collaborated with Leloir on research into carbohydrate metabolism. Cardini was a close collaborator in the laboratory that identified sugar nucleotides.
UDP-glucose: A sugar nucleotide that donates glucose in biochemical reactions, including glycogen synthesis. Leloir’s group identified UDP-glucose as a key intermediate in carbohydrate metabolism.
Bernardo Houssay Institute: A research institute in Buenos Aires associated with physiologist Bernardo Houssay and Argentine biomedical science. Leloir’s early research unfolded in Houssay’s laboratory and scientific circle.
Congenital disorder of glycosylation: A group of inherited diseases caused by defects in the formation or processing of glycoproteins and glycolipids. Research on sugar-nucleotide pathways helped establish the biochemical framework for understanding glycosylation defects.
Raúl Trucco: An Argentine biochemist who worked with Leloir on sugar-nucleotide research. Trucco contributed to the research group’s early studies of nucleotide-linked sugars.
Galactose metabolism: The biochemical reactions that convert galactose into metabolites usable by cells. Leloir mapped the nucleotide-linked steps by which galactose enters carbohydrate metabolism.

Linked from 2 pages