Mebendazole

Mebendazole is a benzimidazole anthelmintic used to treat intestinal worm infections. It disrupts parasite microtubules and glucose uptake, impairing energy production.

Benzimidazole: A chemical scaffold found in compounds used as medicines, including several drugs against parasitic worms. Mebendazole belongs to this drug-bearing chemical family.
Soil-transmitted helminthiasis: Human infection by intestinal worms transmitted through soil contaminated with parasite eggs or larvae. Mebendazole is used against several worms in this disease group.
Pyrantel pamoate: An anthelmintic that paralyzes susceptible intestinal worms through neuromuscular effects. It offers an alternative for some infections, including pinworm.
Anthelmintic resistance: Reduced susceptibility of parasites to medicines that previously controlled them. Repeated drug exposure in worm populations makes resistance monitoring relevant to mebendazole programs.
Tubulin: A protein that assembles into microtubules, which support cell structure and intracellular transport. Mebendazole binds parasite tubulin and disrupts microtubule formation.
Ascariasis: An intestinal infection caused by the roundworm Ascaris lumbricoides. Mebendazole is one treatment option for this common soil-transmitted infection.
Ivermectin: An antiparasitic medicine used against several worm and arthropod infections. It is preferred for some parasites that mebendazole does not reliably treat.
World Health Organization: A United Nations agency that coordinates international public-health work and issues health guidance. Its recommendations inform preventive chemotherapy programs that may use mebendazole.
Microtubule: A hollow filament made of tubulin that helps organize cells and move materials within them. Disrupting parasite microtubules impairs glucose uptake and other essential functions.
Trichuriasis: An intestinal infection caused by the whipworm Trichuris trichiura. This infection is among the established targets of mebendazole treatment.

Linked from 5 pages

Ascaris lumbricoidesRelated: It is another standard treatment that acts against adult Ascaris.