Niclosamide

Niclosamide is a salicylanilide drug used to treat tapeworm infections and control aquatic snails. It disrupts energy production in susceptible organisms.

Oxidative phosphorylation: The mitochondrial process that uses electron transport to drive ATP synthesis. Niclosamide disrupts energy production by uncoupling this process in susceptible organisms.
Taeniasis: An intestinal infection caused by adult tapeworms of the genus Taenia. Niclosamide is used to treat intestinal Taenia infections.
Salicylanilide: An organic compound containing salicylic-acid and aniline-derived structural features. Niclosamide belongs to this chemical class, whose members include other antiparasitic agents.
Biocide: A substance used to kill or control harmful organisms. Niclosamide functions as a biocide when applied to aquatic snail populations.
Protonophore: A molecule that transports protons across a membrane, dissipating a proton gradient. Niclosamide acts as a protonophore, weakening the gradient that powers ATP synthesis.
Diphyllobothriasis: An intestinal infection caused by fish tapeworms of the genus Dibothriocephalus, formerly Diphyllobothrium. Niclosamide has been used to treat intestinal fish-tapeworm infections.
Anilide: An organic compound containing a carbonyl group bonded to a nitrogen atom derived from aniline. The anilide structure is part of the chemical framework named by niclosamide’s class.
Non-target organism: An organism affected by a control measure despite not being its intended target. Niclosamide can harm aquatic organisms beyond the snails it is applied to control.
Mitochondrion: A membrane-bound organelle that produces much of a eukaryotic cell’s ATP. Mitochondrial energy production is a principal target of niclosamide’s uncoupling action.
Praziquantel: An antiparasitic drug used to treat infections caused by many flatworms. It is a commonly used alternative for intestinal tapeworm infections treated with niclosamide.

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Taenia soliumRelated: It can clear adult intestinal T. solium worms, reducing egg shedding.