Knowra Olanzapine Olanzapine Olanzapine is an atypical antipsychotic medication used to treat schizophrenia and bipolar disorder. It acts on several neurotransmitter receptors and can cause substantial weight gain and metabolic changes.
Dopamine D2 receptor : A G protein-coupled receptor through which dopamine influences movement, motivation, and other functions. Olanzapine’s blockade of this receptor contributes to its antipsychotic effects.
Schizophrenia : A psychiatric disorder involving changes in perception, thought, emotion, and behavior. Olanzapine is used to treat schizophrenia in adults and, in some settings, adolescents.
Weight gain : An increase in body mass that can result from changes in appetite, metabolism, activity, or other factors. Olanzapine commonly causes weight gain, sometimes rapidly and substantially.
Clozapine : An atypical antipsychotic used especially for treatment-resistant schizophrenia and reducing recurrent suicidal behavior. Clozapine has distinctive evidence and monitoring demands, while olanzapine is often used earlier in treatment.
Serotonin 5-HT2A receptor : A serotonin receptor involved in neural signaling, perception, and mood. Olanzapine blocks this receptor, shaping its effects alongside dopamine blockade.
Bipolar disorder : A mood disorder marked by episodes of mania or hypomania and often depression. Olanzapine treats manic or mixed episodes and can help prevent recurrence.
Type 2 diabetes : A chronic disorder in which the body cannot regulate blood glucose effectively because of insulin resistance and impaired insulin production. Olanzapine can raise blood glucose and increase diabetes risk, particularly alongside weight gain.
Risperidone : An atypical antipsychotic used to treat schizophrenia, bipolar disorder, and other conditions. Risperidone generally has a different balance of metabolic, hormonal, and movement-related risks.
Histamine H1 receptor : A histamine receptor found in the brain and other tissues that contributes to wakefulness and appetite regulation. Olanzapine’s strong H1 blockade is associated with sedation and increased appetite.
Olanzapine–fluoxetine combination : A combination medication containing olanzapine and the antidepressant fluoxetine. This combination is used for bipolar depression and treatment-resistant depression.
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