Paroxetine

Paroxetine is a selective serotonin reuptake inhibitor prescribed for depression, anxiety disorders, and other psychiatric conditions. It increases serotonin signaling by inhibiting serotonin reuptake.

Serotonin transporter: A membrane protein that clears serotonin from the space between neurons by transporting it back into cells. Paroxetine inhibits this transporter, slowing serotonin reuptake.
Major depressive disorder: A mood disorder marked by persistent depressed mood or loss of interest and other symptoms that impair functioning. Paroxetine is prescribed to treat episodes of this disorder.
Fluoxetine: A selective serotonin reuptake inhibitor used for depression and several other conditions, with a long-lasting active metabolite. Its long half-life contrasts with paroxetine’s greater risk of withdrawal symptoms.
Pregnancy and antidepressants: The clinical evaluation of antidepressant benefits and risks during pregnancy. Paroxetine has specific pregnancy safety concerns that can affect treatment decisions.
Selective serotonin reuptake inhibitor: An antidepressant class that increases serotonin signaling by inhibiting its reuptake from synapses. Paroxetine is a member of this drug class.
Generalized anxiety disorder: An anxiety disorder involving excessive, difficult-to-control worry across multiple areas of life. This is one of paroxetine’s established treatment indications.
Sertraline: A selective serotonin reuptake inhibitor used for depression and multiple anxiety-related disorders. It is a commonly considered SSRI alternative with a different interaction profile.
Serotonin syndrome: A potentially life-threatening reaction to excessive serotonergic activity, often involving interacting medicines. Combining paroxetine with other serotonergic drugs can raise this risk.
Serotonin: A neurotransmitter involved in mood, sleep, appetite, and other functions. Paroxetine alters signaling by this neurotransmitter.
Panic disorder: An anxiety disorder involving recurrent unexpected panic attacks and concern about further attacks. Paroxetine can reduce panic attacks and related anticipatory anxiety.

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