Knowra Post-inflammatory hyperpigmentation Post-inflammatory hyperpigmentation Post-inflammatory hyperpigmentation is darkening of skin that develops after inflammation or injury. It results from excess melanin production or pigment deposited deeper in the skin.
Melanogenesis : The biological process by which melanocytes produce melanin pigment. Inflammatory signals can stimulate this pigment-producing process.
Acne vulgaris : A chronic skin condition involving clogged hair follicles, inflammation, and lesions such as comedones, papules, and pustules. Acne lesions often leave dark marks after the active breakout settles.
Hydroquinone : A topical skin-lightening medicine that reduces melanin production by inhibiting tyrosinase. It is used to fade some forms of epidermal post-inflammatory pigment.
Melasma : A chronic acquired pigmentation disorder that causes symmetrical brown patches, often on the face. Melasma is not necessarily preceded by a visible inflammatory injury.
Epidermis : The outermost layer of skin, forming a protective barrier over the dermis. Pigment confined to this layer often fades as epidermal cells renew.
Melanocyte : A pigment-producing cell that makes melanin and transfers it to surrounding skin cells. These cells produce the excess melanin behind many dark marks.
Atopic dermatitis : A chronic inflammatory skin disease marked by itchy, relapsing eczema and a weakened skin barrier. Repeated eczema inflammation can leave areas of darker pigmentation.
Azelaic acid : A naturally occurring dicarboxylic acid used topically to treat acne and pigmentation disorders. It can address both acne inflammation and resulting dark marks.
Solar lentigo : A sharply defined pigmented spot associated with cumulative ultraviolet exposure. Unlike this condition, it is linked chiefly to sun exposure rather than a prior lesion.
Dermis : The connective-tissue layer beneath the epidermis, containing blood vessels, nerves, and structural proteins. Melanin deposited here can persist longer than pigment in the epidermis.
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