Prednisolone

Prednisolone is a synthetic glucocorticoid corticosteroid that reduces inflammation and suppresses immune activity by activating glucocorticoid receptors.

Glucocorticoid receptor: A steroid-activated transcription factor that regulates genes involved in metabolism, inflammation, and immune function. Prednisolone binds this receptor to alter inflammatory and immune signaling.
Asthma: A chronic airway disease marked by variable inflammation, narrowing, and breathing difficulty. Prednisolone can treat severe exacerbations by reducing airway inflammation.
Prednisone: A synthetic corticosteroid that the liver converts into the active drug prednisolone. It is an oral alternative that requires metabolic activation, unlike prednisolone.
Glucocorticoid-induced osteoporosis: Bone loss and fracture risk caused by prolonged or repeated exposure to glucocorticoid medicines. Long-term prednisolone can impair bone formation and increase fracture risk.
Corticosteroid: A class of steroid hormones and medicines that includes glucocorticoids and mineralocorticoids. Prednisolone belongs to the glucocorticoid branch of this wider family.
Glucocorticoid: A class of steroid hormones and medicines that regulate metabolism and suppress inflammation and immune activity. Prednisolone is a synthetic member of this broader drug and hormone class.
Rheumatoid arthritis: An autoimmune disease that causes chronic inflammation of joints and can damage other tissues. Prednisolone may provide short-term control while longer-term therapies take effect.
Dexamethasone: A potent, long-acting synthetic glucocorticoid with negligible mineralocorticoid activity. It generally lasts longer and has greater glucocorticoid potency than prednisolone.
Adrenal insufficiency: A condition in which the adrenal glands do not produce enough cortisol for the body's needs. After prolonged treatment, abrupt withdrawal can leave natural cortisol production inadequate.
Glucocorticoid potency: A comparative measure of a glucocorticoid's ability to produce effects at a given dose. Potency comparisons help convert prednisolone doses to those of other corticosteroids.

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CortisoneCompared with: It acts directly, whereas cortisone requires conversion to cortisol.