Knowra Quetiapine Quetiapine Quetiapine is an atypical antipsychotic medication used for schizophrenia and bipolar disorder, and as an adjunctive treatment for major depressive disorder. Its effects involve several neurotransmitter receptors, and it can cause sedation and metabolic side effects.
Dopamine D2 receptor : A G protein-coupled receptor through which dopamine influences movement, motivation, and psychosis-related processes. Quetiapine's relatively transient blockade of this receptor contributes to its antipsychotic action.
Schizophrenia : A mental disorder involving psychosis, changes in cognition, and disruptions to motivation and functioning. Quetiapine is used to reduce psychotic symptoms and help prevent their recurrence.
Metabolic syndrome : A cluster of abdominal obesity, elevated blood pressure, abnormal blood lipids, and impaired glucose regulation. Quetiapine can contribute to weight gain and metabolic changes that raise this concern.
Risperidone : An atypical antipsychotic used for schizophrenia, bipolar disorder, and irritability associated with autism. Compared with risperidone, quetiapine generally causes less prolactin elevation but more sedation.
Serotonin 5-HT2A receptor : A serotonin receptor involved in perception, cognition, and regulation of dopamine signaling. Quetiapine blocks this receptor, shaping its effects alongside dopamine D2 blockade.
Bipolar disorder : A mood disorder characterized by episodes of depression and mania or hypomania. Quetiapine treats acute manic and depressive episodes and can help prevent recurrence.
Sedation : Reduced alertness or responsiveness, often caused by medication or other substances. Sedation is common with quetiapine and can affect daytime functioning and fall risk.
Olanzapine : An atypical antipsychotic used for schizophrenia and bipolar disorder, often associated with substantial metabolic effects. Both can cause weight gain, while quetiapine's sedation and olanzapine's metabolic burden often shape comparisons.
Histamine H1 receptor : A histamine receptor that helps regulate wakefulness, appetite, and allergic responses. Quetiapine's strong H1 antagonism helps explain its prominent sedation and potential weight gain.
Major depressive disorder : A mood disorder marked by persistent depressed mood or loss of interest and related symptoms. Quetiapine is approved in some settings as an adjunct when antidepressant treatment alone is insufficient.
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