Knowra Rhabdomyolysis Rhabdomyolysis Rhabdomyolysis is the breakdown of skeletal muscle fibers, releasing myoglobin, electrolytes, and other cellular contents into the bloodstream. It can cause acute kidney injury and dangerous electrolyte disturbances.
Myoglobinuria : Myoglobin in urine, often producing reddish-brown discoloration after muscle breakdown. Filtered myoglobin gives urine its characteristic color and can contribute to kidney injury.
Crush syndrome : A systemic illness caused by prolonged compression and subsequent reperfusion of injured muscle. It is a severe trauma-related form of rhabdomyolysis with substantial kidney and electrolyte risks.
Serum creatine kinase test : A blood test measuring creatine kinase, an enzyme released by damaged muscle and other tissues. A markedly elevated result supports muscle breakdown and helps monitor its course.
Skeletal muscle : Striated muscle tissue attached to bones and usually controlled voluntarily. Rhabdomyolysis specifically involves injury and breakdown of skeletal muscle.
Myositis : Inflammation of muscle tissue, caused by autoimmune disease, infection, or other factors. Myositis is defined by inflammation, while rhabdomyolysis denotes extensive muscle-cell breakdown.
Acute kidney injury : A rapid decline in kidney function that disrupts waste removal and fluid or electrolyte balance. Myoglobin, dehydration, and renal vasoconstriction can combine to damage the kidneys.
Exertional rhabdomyolysis : Muscle breakdown associated with strenuous physical activity, sometimes amplified by heat or illness. Extreme exercise can injure muscle enough to release large quantities of cellular contents.
Urinalysis : Laboratory examination of urine for cells, chemicals, and other substances. A heme-positive dipstick with few red cells can suggest myoglobin in the urine.
Myocyte : A muscle cell specialized to contract and generate force. Rhabdomyolysis disrupts muscle cells and releases their intracellular contents.
Myalgia : Muscle pain, which may occur with or without measurable muscle injury. Pain alone does not establish the muscle breakdown that defines rhabdomyolysis.
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