Knowra Schizosaccharomyces pombe Schizosaccharomyces pombe Schizosaccharomyces pombe is a unicellular fission yeast used to study cell division and other eukaryotic processes. It grows by elongating and divides across its middle, producing two similarly sized daughter cells.
Fission yeast cell cycle : The sequence of growth, DNA replication, and division through which fission yeast produces daughter cells. Its orderly progression makes this yeast useful for tracking cell-cycle control.
Yeast : Single-celled fungi that reproduce through budding or fission and include important laboratory models. Fission yeast belongs to this diverse group of unicellular fungi.
Cell-cycle checkpoint : A regulatory system that delays cell-cycle progression when critical events remain incomplete or damage is detected. Fission yeast mutants helped identify checkpoint controls that pause division after DNA damage.
Urs Leupold : A Swiss geneticist who established foundational methods and strains for studying fission yeast. His work helped make Schizosaccharomyces pombe a practical genetic model.
Saccharomyces cerevisiae : A budding yeast widely used in genetics, biotechnology, and studies of eukaryotic cell biology. Unlike fission yeast, it reproduces by budding and has a different cell-cycle organization.
Cdc2 : A cyclin-dependent kinase that regulates cell-cycle transitions in fission yeast and other eukaryotes. Its discovery in fission yeast helped reveal how kinases govern cell-cycle progression.
Eukaryote : An organism whose cells contain a nucleus and other membrane-bound compartments. Its conserved cellular machinery makes it a model for eukaryotic biology.
DNA damage response : Cellular pathways that detect DNA lesions and coordinate repair, replication, or cell-cycle arrest. Its genetics revealed conserved responses that protect cells from damaged DNA.
Paul Nurse : A British cell biologist whose research on fission yeast revealed key controls of the cell cycle. His experiments connected fission yeast genes to conserved cell-cycle regulation.
Budding yeast cell cycle : The sequence of growth, DNA replication, and division in Saccharomyces cerevisiae, marked by bud formation. Its asymmetric budding contrasts with the fission yeast's medial division.
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