Selegiline

Selegiline is an irreversible inhibitor of monoamine oxidase B used to treat Parkinson’s disease and, in a transdermal formulation, major depressive disorder.

Monoamine oxidase B: Monoamine oxidase B is an enzyme that breaks down dopamine and other monoamines in the brain. Selegiline binds this enzyme irreversibly, reducing dopamine breakdown.
Parkinson's disease: Parkinson’s disease is a progressive neurological disorder marked by movement symptoms and loss of dopamine-producing neurons. Selegiline can reduce motor symptoms as an adjunct to other Parkinson’s treatments.
Rasagiline: Rasagiline is an irreversible monoamine oxidase B inhibitor used to treat Parkinson’s disease. It shares selegiline’s target but is not metabolized into amphetamine-like compounds.
Orthostatic hypotension: Orthostatic hypotension is a fall in blood pressure on standing that can cause dizziness or fainting. Selegiline may contribute to postural blood-pressure drops, especially alongside other Parkinson’s medicines.
Dopamine: Dopamine is a neurotransmitter involved in movement, motivation, reward, and several other brain functions. Slowing dopamine breakdown helps compensate for dopamine loss in Parkinson’s disease.
Major depressive disorder: Major depressive disorder is a mental disorder characterized by persistent depressed mood or loss of interest and related symptoms. The selegiline transdermal patch is approved for treating major depressive disorder.
Safinamide: Safinamide is a reversible monoamine oxidase B inhibitor used as an adjunct in Parkinson’s disease. Its reversible inhibition contrasts with selegiline’s irreversible binding to MAO-B.
Dyskinesia: Dyskinesia is involuntary, often flowing movement that can occur in Parkinson’s disease, particularly during dopaminergic treatment. Increased dopaminergic effects from selegiline can worsen levodopa-associated dyskinesia.
Irreversible enzyme inhibitor: An irreversible enzyme inhibitor permanently inactivates its target enzyme through a stable chemical interaction. Selegiline’s lasting enzyme inactivation means its effects outlast its presence in blood.
Selegiline transdermal patch: The selegiline transdermal patch delivers the drug through the skin for treatment of major depressive disorder. This formulation allows antidepressant dosing while requiring attention to dietary tyramine at higher patch strengths.

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