Knowra Sepsis Sepsis Sepsis is life-threatening organ dysfunction caused by a dysregulated response to infection. It can progress rapidly to septic shock, in which circulatory and metabolic abnormalities sharply increase the risk of death.
Dysregulated Host Response : An immune response whose intensity, duration, or targeting causes harm to the body. Sepsis begins when infection provokes a harmful, poorly controlled host response.
Sepsis-3 : The 2016 international consensus definitions of sepsis and septic shock. These definitions frame sepsis as infection-associated, life-threatening organ dysfunction.
Infection : The invasion and multiplication of microorganisms in a host, which may cause tissue injury or disease. Infection is the trigger required by the clinical definition of sepsis.
Bacteremia : The presence of bacteria in the bloodstream, which may be transient or clinically significant. Bacteria in blood can occur without sepsis, and sepsis can occur without bacteremia.
Post-Sepsis Syndrome : A collection of physical, cognitive, and psychological problems that can persist after sepsis. Survivors may face lasting effects after the acute infection and organ dysfunction resolve.
Endothelial Dysfunction : Impaired function of the cells lining blood vessels, affecting vascular tone, barrier integrity, and clotting. Inflammatory injury to vessel linings contributes to leakage, abnormal clotting, and poor tissue perfusion.
Sequential Organ Failure Assessment : A scoring system that tracks dysfunction across six organ systems using clinical and laboratory measures. SOFA helps quantify organ dysfunction associated with suspected infection.
Organ Dysfunction : Impaired function of an organ that disrupts its normal contribution to the body. New or worsening organ dysfunction distinguishes sepsis from infection without sepsis.
Systemic Inflammatory Response Syndrome : A clinical syndrome defined by abnormal temperature, heart rate, respiratory rate, or white blood cell count. SIRS can arise from infectious or noninfectious causes and is not equivalent to sepsis.
Post-Intensive Care Syndrome : New or worsening physical, cognitive, or mental health impairments that persist after critical illness. Sepsis survivors treated in intensive care may experience this broader recovery syndrome.
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