Knowra Systemic lupus erythematosus Systemic lupus erythematosus Systemic lupus erythematosus (SLE) is a chronic autoimmune disease in which immune activity can inflame multiple organs, with symptoms that often vary over time.
Antinuclear antibody : An antibody that binds structures in a cell nucleus, commonly detected in autoimmune disease testing. Antinuclear antibodies are frequent in SLE, though their presence alone does not establish the diagnosis.
American College of Rheumatology classification criteria : Research criteria used to classify systemic lupus erythematosus based on clinical and immunologic findings. They organize common SLE features but are not a substitute for clinical diagnosis.
Acute cutaneous lupus erythematosus : A lupus skin disease that causes acute eruptions, often including a photosensitive rash across the cheeks and nose. The malar rash is a familiar visible manifestation, but skin findings alone do not define systemic disease.
Rheumatoid arthritis : A chronic autoimmune disease that primarily inflames synovial joints and can cause progressive joint damage. Joint pain occurs in both diseases, but SLE more characteristically combines arthritis with multisystem manifestations.
Morris Ziff : An American rheumatologist whose research helped establish antinuclear antibodies as a feature of systemic lupus erythematosus. His work contributed to the immunologic framework used to understand and identify SLE.
Anti-double-stranded DNA antibody : An autoantibody directed against double-stranded DNA, associated particularly with systemic lupus erythematosus. Its levels can track disease activity in some people, especially when the kidneys are involved.
Systemic Lupus International Collaborating Clinics classification criteria : A set of research classification criteria for SLE that requires an immunologic criterion and combines clinical and laboratory findings. These criteria illustrate how classification balances organ findings with evidence of autoimmunity.
Discoid lupus erythematosus : A chronic cutaneous lupus condition marked by thick, scaly lesions that can scar, especially on the face and scalp. It can occur with or without SLE, distinguishing skin-limited disease from systemic involvement.
Systemic sclerosis : An autoimmune connective-tissue disease characterized by fibrosis and vascular abnormalities affecting skin and internal organs. It shares autoimmune features with SLE but is distinguished by prominent tissue fibrosis and skin thickening.
Edmund L. Dubois : An American physician and researcher known for clinical studies that helped define systemic lupus erythematosus. His clinical descriptions advanced recognition of SLE as a disease affecting multiple organ systems.
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