Tobramycin

Tobramycin is an aminoglycoside antibiotic that inhibits bacterial protein synthesis. It treats serious infections, including some lung, eye, and bloodstream infections.

Aminoglycosides: A class of antibiotics that disrupt bacterial protein synthesis and commonly cause ear or kidney toxicity. Tobramycin belongs to this antibiotic family and shares its characteristic ribosomal action.
Cystic fibrosis: An inherited disorder that causes thick secretions and chronic infection in the lungs and other organs. Inhaled tobramycin suppresses chronic Pseudomonas aeruginosa infection in many people with this disease.
Gentamicin: An aminoglycoside antibiotic used for serious infections caused by susceptible bacteria. It shares tobramycin's class and toxicity concerns but differs in activity against particular organisms.
Streptomyces tenebrarius: A soil bacterium that produces tobramycin and related aminoglycoside compounds. Tobramycin was isolated from this microorganism.
Bacterial 30S ribosomal subunit: The small subunit of bacterial ribosomes, which reads messenger RNA during protein synthesis. Tobramycin binds this subunit, disrupting accurate translation.
Pseudomonas aeruginosa: A Gram-negative bacterium that causes opportunistic infections, especially in hospitals and damaged lungs. This pathogen is a major target of inhaled and intravenous tobramycin.
Amikacin: An aminoglycoside antibiotic often used against bacteria resistant to other drugs in its class. Amikacin can retain activity against some isolates resistant to tobramycin.
Bacterial infection: The invasion and multiplication of bacteria in or on a host, causing tissue damage or disease. Tobramycin is used only when a susceptible bacterial infection warrants antibiotic treatment.
Protein synthesis inhibitor: A substance that slows or stops the production of proteins in cells. Tobramycin's antibacterial effect comes from interfering with this process.
Ophthalmic medication: A medication formulated for application to the eye. Tobramycin eye drops and ointments treat susceptible bacterial eye infections.

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