Linked from

The 24 pages that link to Acetylcholinesterase, each with the reason it gives.

• AcetylcholineRelated: Its breakdown of acetylcholine terminates signaling at synapses and neuromuscular junctions.

• Neuromuscular junctionRelated: It terminates the junction’s signal by clearing acetylcholine from the cleft.

• AlkaloidRelated: Physostigmine inhibits this enzyme, increasing acetylcholine at nerve synapses.

• Myasthenia gravisRelated: Blocking this enzyme temporarily increases acetylcholine available to stimulate muscle receptors.

• Organophosphate poisoningRelated: Organophosphates inhibit this enzyme, allowing acetylcholine to build up.

• Motor neuronRelated: It ends the motor neuron's signal so muscle activation does not persist.

• NeurotoxinRelated: Organophosphate neurotoxins cause acetylcholine to accumulate by inhibiting this enzyme.

• PralidoximeRelated: Pralidoxime restores this enzyme after organophosphate inhibition.

• Cholinergic crisisRelated: Inhibition of this enzyme can let acetylcholine accumulate to dangerous levels.

• Acetylcholinesterase inhibitorRelated: The inhibitor acts by reducing this enzyme’s catalytic activity.

• Nerve agentRelated: Most nerve agents inhibit this enzyme, allowing acetylcholine to accumulate.

• SarinRelated: Sarin disables this enzyme, preventing normal termination of nerve signals.

• Synaptic cleftRelated: At cholinergic synapses, it clears acetylcholine from the cleft and ends receptor activation.

• Tropane alkaloidRelated: It provides a contrast to tropane drugs that block acetylcholine receptors rather than break down the transmitter.

• MalathionRelated: Malathion’s active metabolite inhibits this enzyme, causing acetylcholine to accumulate.

• Monoamine transporterCompared with: Acetylcholine is cleared enzymatically, unlike monoamines commonly cleared by uptake.

• Novichok agentsRelated: Novichok agents inhibit this enzyme, causing acetylcholine to accumulate.

• NeostigmineRelated: Neostigmine reversibly inhibits this enzyme, slowing acetylcholine breakdown.

• DonepezilRelated: Donepezil reversibly inhibits this enzyme, slowing acetylcholine breakdown.

• Poisoning of Alexei NavalnyRelated: Its inhibition explains the severe neurological effects associated with nerve-agent exposure.

• SomanRelated: Soman disables this enzyme, allowing acetylcholine to accumulate.

• SolanineRelated: Solanine exposure has been associated with inhibition of this enzyme, though its toxicity is not fully explained by that mechanism.

• MuscarineRelated: Muscarine resists this enzyme, helping its receptor activation persist.

• Tetraethyl pyrophosphateRelated: Tetraethyl pyrophosphate inhibits this enzyme, causing acetylcholine to accumulate.