KnowraAlpha-1 antitrypsin deficiencyLinked fromLinked fromThe 4 pages that link to Alpha-1 antitrypsin deficiency, each with the reason it gives.All 4Related 4Chronic obstructive pulmonary diseaseRelated: It is an uncommon genetic cause of emphysema and can lead to COPD at a younger age.Endoplasmic reticulumRelated: Misfolded protein retention in the ER contributes to liver injury in this disorder.EmphysemaRelated: It can cause emphysema, often at a younger age and with little smoking exposure.ElastinRelated: Unopposed elastase activity can degrade lung elastin and contribute to emphysema.