Linked from
The 15 pages that link to Antigenic drift, each with the reason it gives.
AntigenRelated: Changing viral antigens can reduce protection from prior infection or vaccination.
InfluenzaRelated: Drift helps explain why influenza vaccines are updated regularly.
Neutralizing AntibodyRelated: Drift can alter antibody targets and weaken existing neutralization.
VirologyRelated: Drift can reduce existing immunity and complicate vaccine design.