Linked from

The 26 pages that link to Beta-lactamase, each with the reason it gives.

• Antimicrobial resistanceBroader topic: These enzymes provide a well-studied mechanism of resistance to penicillins and related drugs.

• Antibiotic resistanceRelated: Enzymatic drug destruction is a widespread route to resistance.

• PenicillinRelated: Bacteria producing these enzymes can destroy penicillin before it reaches its targets.

• Gram-negative bacteriaRelated: Periplasmic beta-lactamases can destroy drugs before they reach their targets.

• Beta-lactam antibioticCompared with: These enzymes directly undermine the chemical feature the drug class depends on.

• Penicillin-binding proteinsCompared with: Unlike altered target proteins, beta-lactamases protect bacteria by destroying the drug.

• AmoxicillinCompared with: Many beta-lactamases destroy amoxicillin before it can inhibit cell-wall enzymes.

• Beta-lactam ringCompared with: It opens the ring before the antibiotic can inactivate its target.

• CephalosporinRelated: Many β-lactamases inactivate cephalosporins before they reach their targets.

• CeftriaxoneRelated: Some beta-lactamases can inactivate ceftriaxone before it reaches its targets.

• Extended-spectrum beta-lactamaseNarrower topic: ESBLs are a subset of beta-lactamases distinguished by their expanded activity against cephalosporins.

• Penicillin GCompared with: Some β-lactamases inactivate Penicillin G before it can block cell-wall enzymes.

• CefazolinRelated: Beta-lactamases can destroy cefazolin before it reaches its targets.

• AztreonamRelated: These enzymes can break down aztreonam and limit its activity.

• CeftazidimeRelated: These enzymes can hydrolyze ceftazidime and make bacteria resistant.

• CefiximeRelated: Some beta-lactamases can hydrolyze cefixime and undermine treatment.

• Clavulanic acidRelated: Clavulanic acid inhibits many of these enzymes, protecting susceptible antibiotics.

• FlucloxacillinNarrower topic: Staphylococcal penicillinase is one beta-lactamase that flucloxacillin resists.

• MethicillinNarrower topic: Penicillinase is a member of this family, the resistance methicillin was built to evade.

• BenzylpenicillinCompared with: These enzymes can destroy benzylpenicillin before it reaches its bacterial targets.

• AmpicillinRelated: Beta-lactamase production is a common reason bacteria resist ampicillin.

• CefalexinRelated: Some beta-lactamases can make bacteria resistant to cefalexin.

• CefuroximeRelated: Some beta-lactamases can break down cefuroxime and reduce its effectiveness.

• CloxacillinRelated: Cloxacillin’s bulky side chain resists many staphylococcal forms of this enzyme.

• MeropenemRelated: Some beta-lactamases hydrolyze meropenem and confer resistance.

• PhenoxymethylpenicillinCompared with: Beta-lactamase production can make bacteria resistant to penicillin V.