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The 14 pages that link to De novo mutation, each with the reason it gives.

• Autosomal dominant inheritanceRelated: A dominant condition can begin in a family without an affected parent.

• Rare diseaseRelated: It can cause a rare disease without any family history.

• Genetic disorderRelated: A spontaneous mutation can cause a disorder with no prior family history.

• Osteogenesis imperfectaRelated: A substantial number of affected people have no family history because of a new variant.

• AchondroplasiaRelated: Most achondroplasia cases arise this way, often in the paternal germline.

• Noonan syndromeRelated: Many people with Noonan syndrome have a variant absent from both parents.

• Apert syndromeRelated: Many Apert syndrome cases arise from new FGFR2 variants.

• Pfeiffer syndromeRelated: Many affected people have a new pathogenic variant without a family history.

• Alagille syndromeRelated: Many affected people have a newly arisen variant rather than an affected parent.

• Aicardi syndromeRelated: Aicardi syndrome usually occurs sporadically, although its molecular cause has not been established.

• Cornelia de Lange syndromeRelated: Many affected individuals have a variant absent from both parents.

• Jacobsen syndromeRelated: Many cases result from a new deletion, while some involve inherited chromosome rearrangements.

• Pitt–Hopkins syndromeRelated: Many TCF4 changes causing Pitt–Hopkins syndrome arise de novo.