KnowraDihydrofolate reductaseLinked fromLinked fromThe 6 pages that link to Dihydrofolate reductase, each with the reason it gives.All 6Related 6MethotrexateRelated: Methotrexate inhibits this enzyme, restricting folate-dependent DNA synthesis.FolateRelated: It regenerates active folate after thymidylate synthesis and is a target of antifolate drugs.TrimethoprimRelated: Trimethoprim binds the bacterial enzyme and blocks this step in folate recycling.Folic acidRelated: This enzyme performs the reduction steps that activate folic acid for metabolism.PyrimethamineRelated: Pyrimethamine inhibits the parasite form of this enzyme.Gertrude B. ElionRelated: This enzyme became a target for drugs against cancer cells and infectious organisms.