Knowra Drug discovery Drug discovery Drug discovery identifies and optimizes compounds that may become medicines, then evaluates promising candidates in preclinical studies before human testing.
Drug target : A biological molecule or process whose modulation is intended to produce a therapeutic effect. Target selection defines the biological problem a discovery program seeks to alter.
Assay : A procedure for measuring a biological activity, chemical property, or other quantity. Discovery decisions depend on assays that measure target engagement or desired effects.
Target-based drug discovery : Drug discovery that begins by selecting a biological target and testing compounds for effects on it. This strategy makes target validation and target-focused assays central to candidate selection.
Drug development : The broader process of turning a therapeutic candidate into an approved, manufactured medicine. It includes discovery as well as clinical testing, regulatory review, and production.
High-throughput screening : Automated testing of large compound libraries to find substances with activity in a chosen assay. Screening can reveal initial active compounds against a target or assay.
Pharmacology : The study of how drugs interact with biological systems and how organisms respond to them. It connects molecular activity to effects in cells, tissues, and organisms.
Phenotypic screening : Screening compounds for desired effects in cells or organisms without requiring a predetermined molecular target. It can find useful biological effects when the responsible target is unknown.
Clinical trial : A planned study in people that evaluates a medical intervention’s safety or effects. Human trials generally begin after discovery and preclinical work nominate a candidate.
Hit-to-lead : The process of validating screening hits and improving them into promising lead compounds. It turns early assay activity into compounds suitable for systematic optimization.
Pharmacokinetics : The study of how a substance is absorbed, distributed, metabolized, and eliminated by the body. A potent compound may fail if it cannot reach and remain at its site of action.
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