Linked from

The 32 pages that link to Glutamate, each with the reason it gives.

• Amino acidBroader topic: Glutamate is both a protein building block and a major excitatory neurotransmitter.

• NeurotransmitterBroader topic: It is central to fast excitation and many forms of synaptic plasticity.

• AcetylcholineCompared with: Glutamate dominates fast excitation in the brain, while acetylcholine often modulates circuit activity.

• Citric acid cycleRelated: Transamination of α-ketoglutarate links cycle carbon to glutamate and amino-acid metabolism.

• GlutathioneRelated: Glutamate forms the first residue in glutathione’s unusual peptide linkage.

• UmamiRelated: Free glutamate is the main food compound responsible for umami.

• GABARelated: GABA is synthesized from glutamate, linking the main inhibitory and excitatory transmitters.

• Synaptic plasticityRelated: Many studied forms of excitatory plasticity depend on glutamate signaling.

• KetamineRelated: Ketamine’s effects involve altered glutamate signaling, including downstream synaptic changes.

• Long-term potentiationRelated: Its release activates receptors that initiate many forms of potentiation.

• Urea cycleRelated: It channels amino-group nitrogen toward ammonia and aspartate, feeding the cycle.

• Soy sauceRelated: Protein breakdown releases glutamate, a major source of soy sauce’s savory taste.

• Alcohol withdrawal syndromeRelated: Chronic alcohol use alters glutamate signaling, which can become excessive after alcohol is stopped.

• NMDA receptorRelated: It binds NMDA receptors and helps initiate channel opening.

• DashiBroader topic: It is the savory compound that links kombu dashi to many other foods.

• LamotrigineRelated: Lamotrigine can reduce release of glutamate, a driver of neuronal excitation.

• Alcohol intoxicationRelated: Alcohol inhibits NMDA-type glutamate receptors, weakening excitation and disrupting memory formation.

• Glutamic acidRelated: The names distinguish the protonated acid from the form most common in cells.

• GabapentinRelated: Gabapentin can reduce release of excitatory transmitters, including glutamate, in some experimental settings.

• KojiRelated: Koji proteases help release glutamate from proteins in fermented ingredients.

• Oyster sauceRelated: Oyster extracts contain glutamate, which helps give the sauce its deep savory taste.

• Delirium tremensRelated: Withdrawal can leave excitatory signaling unrestrained, contributing to agitation and seizures.

• PregabalinRelated: Reduced glutamate release is among the effects associated with pregabalin’s channel binding.

• AlanineRelated: Alanine transaminase transfers alanine’s amino group to α-ketoglutarate, forming glutamate.

• Aspartic acidCompared with: Glutamate is the dominant excitatory amino-acid messenger, unlike aspartate’s more limited signaling role.

• GlutamineRelated: Glutamate and glutamine are interconverted in metabolism and in the brain.

• Monosodium glutamateNarrower topic: The glutamate ion, rather than the sodium component, produces the characteristic umami taste.

• OrnithineRelated: Glutamate can supply ornithine synthesis through glutamate-5-semialdehyde and related intermediates.

• Miso soupRelated: Fermented miso and kombu dashi both provide glutamate to the soup.

• PhencyclidineNarrower topic: PCP disrupts signaling by blocking one of glutamate’s major receptor types.

• Alpha-ketoglutaric acidRelated: Adding an amino group to alpha-ketoglutarate produces glutamate.

• VegemiteRelated: Glutamate helps give yeast extract its characteristic savory intensity.