Linked from

The 12 pages that link to Haploinsufficiency, each with the reason it gives.

• Gene expressionRelated: Reduced expression from the remaining functional copy can cause disease.

• Tumor suppressor geneCompared with: Some tumor suppressors can contribute to cancer when one copy is lost, unlike the classic two-hit pattern.

• Dominance (genetics)Compared with: It explains why a loss-of-function allele can show a dominant effect rather than being masked.

• Gene dosageCompared with: It is the consequence of too little dosage for a dosage-sensitive gene.

• Cri du chat syndromeRelated: Reduced dosage of genes in the deleted region can contribute to symptoms.

• Sotos syndromeRelated: Reduced NSD1 function is the main proposed genetic mechanism in Sotos syndrome.

• 1p36 deletion syndromeRelated: Loss of one gene copy can contribute to features of the syndrome.

• Rubinstein–Taybi syndromeRelated: Reduced CREBBP or EP300 activity is a central disease mechanism.

• Smith–Magenis syndromeRelated: Loss of one working RAI1 copy is a central route from genetic change to the syndrome.

• 22q13 deletion syndromeRelated: Loss of one SHANK3 copy can reduce its protein below the level needed for typical synaptic function.

• Jacobsen syndromeRelated: It helps explain effects of genes lost from one chromosome 11 copy.

• Pitt–Hopkins syndromeRelated: Many TCF4 variants cause disease by reducing functional gene dosage.