Linked from

The 15 pages that link to Marfan syndrome, each with the reason it gives.

• Autosomal dominant inheritanceBroader topic: It illustrates variable features and cardiovascular risks in a dominant condition.

• Connective tissueRelated: Fibrillin defects show how matrix proteins affect the skeleton, eyes, and aorta.

• Variable expressivityBroader topic: Clinical severity ranges from mild skeletal findings to serious cardiovascular complications.

• Genotype–phenotype correlationBroader topic: People with related FBN1 variants can show markedly different clinical features.

• Aortic aneurysmRelated: Its weakened connective tissue can predispose the aortic root to aneurysm.

• Aortic dissectionRelated: Aortic root enlargement and weakened connective tissue increase dissection risk.

• Dominance (genetics)Related: Many FBN1 variants act dominantly, including through effects on the fibrillin-1 protein.

• Abdominal aortic aneurysmCompared with: It is a distinct inherited route to aortic aneurysm, unlike the usual abdominal pattern.

• Ehlers–Danlos syndromeCompared with: Both disorders can cause joint laxity, but Marfan syndrome has a distinct pattern and genetic basis.

• HomocystinuriaCompared with: Both conditions can cause long limbs and lens displacement, but their causes and risks differ.

• Ectopia lentisRelated: Its zonular weakness commonly displaces the lens upward and outward.

• Loeys–Dietz syndromeCompared with: It shares aortic risk with Loeys–Dietz syndrome but often has distinctive eye and skeletal findings.

• AphakiaRelated: Its weakened lens-supporting fibers can cause lens displacement and complicate optical correction.

• Mitral valve prolapseRelated: Its connective-tissue abnormalities can predispose to mitral valve prolapse.

• Victor A. McKusickBroader topic: McKusick’s study of this syndrome helped establish his reputation as a medical geneticist.