Meloxicam

Meloxicam is a nonsteroidal anti-inflammatory drug used to reduce pain and inflammation. It is prescribed especially for osteoarthritis and rheumatoid arthritis.

Cyclooxygenase: Cyclooxygenase enzymes produce prostaglandins and other signaling molecules from arachidonic acid. Meloxicam reduces prostaglandin production by inhibiting cyclooxygenase enzymes.
Osteoarthritis: Osteoarthritis is a joint disease involving cartilage breakdown, bone changes, and pain. Meloxicam is commonly prescribed to reduce osteoarthritis pain and inflammation.
Celecoxib: Celecoxib is a nonsteroidal anti-inflammatory drug that selectively inhibits COX-2. Both favor COX-2 inhibition, but celecoxib is more selective.
Peptic ulcer: A peptic ulcer is an open sore in the lining of the stomach or upper small intestine. Meloxicam can increase ulcer and gastrointestinal bleeding risk, especially with longer use.
COX-1: COX-1 is a cyclooxygenase enzyme involved in prostaglandin production, including functions that protect the stomach lining. Meloxicam inhibits COX-1 less strongly than COX-2, but not selectively enough to eliminate related risks.
Rheumatoid arthritis: Rheumatoid arthritis is an autoimmune disease that causes chronic inflammation of the joints and other tissues. Meloxicam can relieve joint symptoms but does not stop the underlying autoimmune disease.
Ibuprofen: Ibuprofen is a nonsteroidal anti-inflammatory drug that reversibly inhibits COX-1 and COX-2. Ibuprofen is a familiar nonselective NSAID used for similar symptoms, often over shorter periods.
Acute kidney injury: Acute kidney injury is a sudden decline in kidney function. NSAID suppression of kidney prostaglandins can impair renal blood flow and trigger injury.
COX-2: COX-2 is a cyclooxygenase enzyme whose activity increases during inflammation and contributes to pain and swelling. Meloxicam preferentially inhibits COX-2, which contributes to its anti-inflammatory action.
Juvenile rheumatoid arthritis: Juvenile rheumatoid arthritis is an older name for forms of chronic inflammatory arthritis beginning in childhood. Oral meloxicam is used for juvenile arthritis in some jurisdictions and age groups.

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PiroxicamCompared with: It shares piroxicam’s oxicam structure but generally has a shorter half-life and different dosing.