Linked from

The 14 pages that link to p53, each with the reason it gives.

• ApoptosisRelated: When damage is severe, p53 can promote the intrinsic apoptotic pathway.

• Cellular senescenceRelated: DNA damage can activate p53, which helps impose senescence by stopping the cell cycle.

• Human papillomavirusRelated: HPV E6 can disable this safeguard, aiding cancer development.

• DNA damage responseRelated: Damage signaling stabilizes p53, which can halt proliferation or trigger cell death.

• Cell-cycle checkpointRelated: Checkpoint signaling can stabilize p53 and induce cell-cycle arrest.

• Programmed cell deathRelated: When damage cannot be repaired, p53 can promote transcription of pro-death genes.

• ProteasomeRelated: Ubiquitin-dependent proteasomal turnover is a major control on p53 abundance.

• Avram HershkoRelated: Ubiquitin-dependent degradation helps control p53 abundance and its effects on cells.

• NucleolusRelated: Nucleolar stress can stabilize p53 by disrupting proteins that normally restrain it.

• Li–Fraumeni syndromeRelated: Li–Fraumeni-associated variants can impair this protein’s protective functions.

• Diamond–Blackfan anemiaRelated: Ribosomal stress can activate p53 signaling and contribute to loss of red-cell precursors.