Linked from

The 26 pages that link to Penicillin-binding proteins, each with the reason it gives.

• PeptidoglycanRelated: Their transglycosylase and transpeptidase activities extend and cross-link the wall.

• PenicillinRelated: Penicillin binds these enzymes and blocks their cell-wall-building activity.

• Bacterial cell wallRelated: They construct the wall’s cross-links and are targets of several beta-lactam antibiotics.

• Beta-lactam antibioticRelated: Beta-lactams bind these enzymes and block their cell-wall cross-linking activity.

• Beta-lactamaseCompared with: These bacterial enzymes are the antibiotic targets; beta-lactamases instead destroy the drugs.

• AmoxicillinRelated: Amoxicillin binds these enzymes and blocks the final cross-linking steps of cell-wall construction.

• Methicillin-resistant Staphylococcus aureusNarrower topic: MRSA's altered PBP2a contrasts with the usual beta-lactam-sensitive targets in susceptible bacteria.

• Beta-lactam ringRelated: The ring acylates their active-site serine, blocking cell-wall cross-linking.

• CephalosporinRelated: Cephalosporins bind these enzymes and block the cross-linking needed for a strong cell wall.

• CeftriaxoneRelated: Ceftriaxone binds these enzymes and blocks the final stages of cell-wall construction.

• CarbapenemRelated: Carbapenems bind these enzymes, disrupting bacterial cell-wall construction.

• Bactericidal antibioticRelated: Beta-lactam antibiotics bind these enzymes, disrupting wall construction and often killing actively growing bacteria.

• Penicillin GRelated: Penicillin G binds these enzymes and disrupts the cross-linking that strengthens the bacterial wall.

• CefazolinRelated: Cefazolin binds these enzymes, stopping cross-linking of the bacterial wall.

• CeftazidimeRelated: Ceftazidime binds these enzymes and disrupts the final stages of cell-wall construction.

• CefiximeRelated: Cefixime binds these enzymes, disrupting the cross-linking needed to build a stable bacterial wall.

• FlucloxacillinRelated: Flucloxacillin binds these enzymes, disrupting cell-wall construction and killing susceptible bacteria.

• MethicillinRelated: Methicillin kills susceptible bacteria by binding these enzymes and disrupting cell-wall construction.

• BenzylpenicillinRelated: Benzylpenicillin binds these enzymes and blocks the final stages of cell-wall construction.

• CefotaximeRelated: Cefotaxime binds these enzymes, disrupting the final steps of cell-wall construction.

• AmpicillinRelated: Ampicillin binds these enzymes, blocking the cross-linking needed to strengthen peptidoglycan.

• CefalexinRelated: Cefalexin binds these enzymes, interrupting the cross-linking that strengthens bacterial cell walls.

• CefuroximeRelated: Cefuroxime binds these enzymes, preventing the cross-linking needed for a stable bacterial wall.

• CloxacillinRelated: Cloxacillin binds these enzymes, preventing the cross-linking needed for a stable cell wall.

• MeropenemRelated: Meropenem binds these enzymes and disrupts the final stages of cell-wall construction.

• PhenoxymethylpenicillinRelated: Penicillin V binds these enzymes, disrupting cell-wall construction.