Linked from

The 12 pages that link to Severe combined immunodeficiency, each with the reason it gives.

• T cellRelated: Severe T-cell defects can leave the body highly vulnerable to infections.

• Hematopoietic stem cell transplantationRelated: Transplantation can establish functional immune-cell production in affected patients.

• ImmunodeficiencyBroader topic: It exemplifies a profound combined defect that threatens survival without early intervention.

• Non-homologous end joiningRelated: Mutations in end-joining proteins can prevent lymphocytes from completing receptor-gene rearrangement.

• ThymusRelated: Some forms compromise thymocyte production or maturation.

• Cell-mediated immunityBroader topic: It exemplifies the severe consequences of losing cellular adaptive immunity.

• Bone-marrow transplantationRelated: Transplantation can establish donor-derived immune-cell production in affected children.

• Primary immunodeficiencyBroader topic: It illustrates how severe combined defects can make ordinary infections life-threatening early in life.

• X-linked agammaglobulinemiaCompared with: T-cell defects distinguish it from the predominantly B-cell developmental block in this disorder.

• ThymocyteNarrower topic: Several forms interrupt signals required for thymocyte survival and maturation.

• David VetterNarrower topic: Vetter’s condition left him unable to mount normal defenses against infections.

• Hemic and Immune SystemsBroader topic: It shows the consequences of failure in essential adaptive immune pathways.