Linked from

The 26 pages that link to Statin, each with the reason it gives.

• AtherosclerosisRelated: Statins lower LDL cholesterol and reduce the risk of atherosclerotic cardiovascular events.

• CholesterolRelated: Statins reduce liver cholesterol synthesis and increase removal of LDL from blood.

• Cardiovascular diseaseRelated: Statins reduce atherosclerotic events by lowering LDL cholesterol and stabilizing plaques.

• Coronary artery diseaseRelated: Statins reduce atherosclerotic risk and are central to secondary prevention.

• Metabolic syndromeRelated: Statins may reduce cardiovascular risk when the overall lipid and risk profile warrants treatment.

• Low-density lipoproteinRelated: Statins reduce LDL chiefly by increasing hepatic removal of LDL particles.

• Familial hypercholesterolemiaRelated: Statins are usually the first-line medicines for lowering LDL in affected people.

• Mevalonate pathwayRelated: Statins directly block the pathway’s regulated, rate-limiting enzyme.

• Secondary preventionRelated: After cardiovascular disease, statins reduce the risk of another event.

• EzetimibeCompared with: Statins lower cholesterol through liver synthesis rather than intestinal absorption.

• Enzyme inhibitionBroader topic: Statins show how enzyme inhibition can reduce cholesterol production.

• HMG-CoA reductaseCompared with: Statins compete at the enzyme’s active site and reduce hepatic cholesterol synthesis.

• Atherosclerotic cardiovascular diseaseRelated: Statins lower cardiovascular event risk by reducing LDL cholesterol and stabilizing plaques.

• Lipid metabolismRelated: Statins therapeutically suppress a rate-limiting step in cholesterol synthesis.

• PCSK9 inhibitorsCompared with: They are usually foundational therapy, while PCSK9 inhibitors are added when LDL remains above target.

• DyslipidemiaRelated: Statins are the principal medication class for reducing LDL-related cardiovascular risk.

• SqualeneCompared with: Statins restrict an upstream pathway that supplies squalene’s precursors.

• SterolRelated: Statins reduce production of the most prominent animal sterol.

• UbiquinoneRelated: The pathway inhibited by statins also supplies precursors for ubiquinone synthesis.

• Statin-associated muscle symptomsNarrower topic: These are the medicines during whose treatment the symptoms are reported.

• Nicotinic acidCompared with: Statins have stronger evidence for preventing cardiovascular events than nicotinic acid therapy.

• RosuvastatinNarrower topic: Rosuvastatin is a later-generation member of this drug class.

• Mevalonic acidCompared with: Statins reduce mevalonate production by blocking its immediate biosynthetic enzyme.

• SimvastatinNarrower topic: Simvastatin belongs to this drug class and shares its core mechanism.

• High cholesterolRelated: Statins are the main drug treatment for reducing cholesterol-related cardiovascular risk.

• Konrad Emil BlochRelated: The pathway Bloch helped establish later supplied the biochemical target for statin therapy.