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The 19 pages that link to Tumor suppressor gene, each with the reason it gives.

• CancerRelated: Cancer can develop when these safeguards are disabled.

• CarcinogenBroader topic: Carcinogen-induced damage can disable these safeguards, allowing abnormal cells to survive.

• Cell cycleRelated: Loss of tumor-suppressor function can remove barriers to cycle progression.

• CarcinogenesisRelated: Loss of tumor-suppressor function removes safeguards against abnormal growth.

• OncogeneCompared with: Tumor suppressors oppose cancer, whereas oncogenes promote it when abnormally activated.

• Skin cancerRelated: Mutations in growth-control genes help damaged skin cells become malignant.

• LeukemiaRelated: Loss of growth control can contribute to leukemic transformation.

• CarcinogenicityBroader topic: Carcinogens can disable cellular safeguards by damaging these genes.

• Radiation-induced cancerRelated: Damage that disables these safeguards can help an irradiated cell become cancerous.

• Cancer researchBroader topic: Their inactivation shows how tumors escape cellular safeguards.

• Somatic cellRelated: Somatic disruption of these genes can remove safeguards against tumor formation.

• MutagenRelated: Mutagen-induced changes can disable these genes and contribute to cancer development.

• Benign tumorRelated: Loss of growth controls can help abnormal cell populations expand.

• NeoplasmRelated: Loss of tumor-suppressor function removes barriers to neoplastic growth.

• Li–Fraumeni syndromeNarrower topic: TP53 is a tumor suppressor whose inherited impairment drives the syndrome.

• Peutz–Jeghers syndromeNarrower topic: STK11 belongs to this gene class, whose failure contributes to cancer predisposition.

• SarcomaRelated: Loss of tumor-suppressor function drives some sarcomas, including leiomyosarcoma.

• Von Hippel–Lindau diseaseNarrower topic: VHL is a tumor suppressor whose inherited and acquired disruption promotes tumor formation.

• History of cancerBroader topic: Its discovery showed that cancer can follow loss of cellular growth controls.