KnowraZinc finger nucleaseLinked fromLinked fromThe 7 pages that link to Zinc finger nuclease, each with the reason it gives.All 7Related 1Compared with 6CRISPR gene editingCompared with: It can target DNA but requires custom protein engineering rather than a guide RNA.Restriction enzymeCompared with: It uses engineered DNA-binding proteins rather than a natural restriction-enzyme recognition system.CRISPRCompared with: The pre-CRISPR method requiring custom protein engineering for every new target.Genome editingCompared with: It was an earlier programmable editing tool that requires custom protein engineering for each target.TALENCompared with: Like TALENs, it uses paired protein-guided nucleases, but its DNA-binding modules differ.Cas9Compared with: The protein-engineering approach Cas9 displaced by making retargeting trivial.History of genetic engineeringRelated: These nucleases were an early programmable approach to targeted genome editing.