Linked from

The 21 pages that link to Amyotrophic lateral sclerosis, each with the reason it gives.

• ElectromyographyRelated: EMG can reveal widespread denervation and reinnervation in its diagnostic evaluation.

• Augmentative and alternative communicationRelated: AAC may preserve communication as speech and movement change over the course of ALS.

• NeurodegenerationBroader topic: It demonstrates neurodegeneration in both upper and lower motor neuron systems.

• Endoplasmic reticulumRelated: ER stress and disrupted protein homeostasis are among the cellular processes studied in ALS.

• PrionCompared with: It involves protein aggregation but is not classified as a prion disease.

• Motor neuronRelated: Motor-neuron loss causes worsening weakness and paralysis.

• DysarthriaRelated: Bulbar muscle weakness in ALS can cause progressively worsening dysarthria.

• Muscle weaknessBroader topic: It demonstrates how motor-neuron loss produces progressive weakness.

• Protein misfoldingBroader topic: Protein aggregation and misfolding are implicated in several genetic and sporadic forms.

• Intrinsically disordered proteinRelated: Dysregulated assembly of proteins with disordered regions is implicated in some forms of the disease.

• Stephen HawkingRelated: Hawking was diagnosed with ALS as a young adult and lived with the disease for decades.

• Jean-Martin CharcotBroader topic: Charcot and Alexis Joffroy described its clinical and pathological features; it was once called Charcot disease.

• Spinal muscular atrophyCompared with: It also causes progressive weakness but is generally not the childhood-onset SMN1 disorder.

• Lower motor neuronBroader topic: Its lower motor neuron damage causes weakness, muscle wasting, and fasciculations.

• Frontotemporal dementiaRelated: It can overlap with frontotemporal dementia, especially in people with C9orf72 expansions.

• Muscle atrophyRelated: Motor neuron loss causes denervation and progressive muscle wasting.

• Chronic traumatic encephalopathyCompared with: Some CTE research reports motor-neuron disease alongside CTE pathology, but the conditions are not interchangeable.

• Lou GehrigNarrower topic: Gehrig’s diagnosis brought wide attention to this disease, commonly called Lou Gehrig’s disease in the United States.

• Hereditary spastic paraplegiaCompared with: Lower motor neuron signs and broader progression distinguish it from many uncomplicated hereditary cases.

• Percy Williams BridgmanRelated: Bridgman died by suicide after receiving a diagnosis of this disease.

• Neurodegenerative diseaseBroader topic: It illustrates degeneration affecting motor pathways in the brain and spinal cord.